Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
Identifieur interne : 000069 ( an2020/Analysis ); précédent : 000068; suivant : 000070Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
Auteurs : Yuan Ke [République populaire de Chine] ; Chaoyan Wu [République populaire de Chine] ; Yifei Zeng [République populaire de Chine] ; Mengge Chen [République populaire de Chine] ; Yonghong Li [République populaire de Chine] ; Conghua Xie [République populaire de Chine] ; Yunfeng Zhou [République populaire de Chine] ; Yahua Zhong [République populaire de Chine] ; Haijun Yu [République populaire de Chine]Source :
- International Journal of Biological Sciences [ 1449-2288 ] ; 2020.
Abstract
Loco-regional recurrence of nasopharyngeal carcinoma (NPC) after radiation therapy is one of the main types of treatment failure. This study is aimed to explore the possible causes of inside-field recurrence of NPC patients in order to develop effective treatment methods. Our study indicated that CD44 and autophagy proteins in tumor tissues of patients with recurrent NPC are higher than that of the relapse free patients. The
Url:
DOI: 10.7150/ijbs.40305
PubMed: 32071548
PubMed Central: 7019136
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in<italic> Vivo</italic></title><author><name sortKey="Ke, Yuan" sort="Ke, Yuan" uniqKey="Ke Y" first="Yuan" last="Ke">Yuan Ke</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; 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Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Yonghong" sort="Li, Yonghong" uniqKey="Li Y" first="Yonghong" last="Li">Yonghong Li</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhou, Yunfeng" sort="Zhou, Yunfeng" uniqKey="Zhou Y" first="Yunfeng" last="Zhou">Yunfeng Zhou</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhong, Yahua" sort="Zhong, Yahua" uniqKey="Zhong Y" first="Yahua" last="Zhong">Yahua Zhong</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yu, Haijun" sort="Yu, Haijun" uniqKey="Yu H" first="Haijun" last="Yu">Haijun Yu</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32071548</idno><idno type="pmc">7019136</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019136</idno><idno type="RBID">PMC:7019136</idno><idno type="doi">10.7150/ijbs.40305</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000596</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000596</idno><idno type="wicri:Area/Pmc/Curation">000596</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000596</idno><idno type="wicri:Area/Pmc/Checkpoint">000063</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000063</idno><idno type="wicri:Area/Ncbi/Merge">000F39</idno><idno type="wicri:Area/Ncbi/Curation">000F39</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F39</idno><idno type="wicri:Area/Main/Merge">000069</idno><idno type="wicri:Area/Main/Curation">000069</idno><idno type="wicri:Area/Main/Exploration">000069</idno><idno type="wicri:Area/an2020/Extraction">000069</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in<italic> Vivo</italic></title><author><name sortKey="Ke, Yuan" sort="Ke, Yuan" uniqKey="Ke Y" first="Yuan" last="Ke">Yuan Ke</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wu, Chaoyan" sort="Wu, Chaoyan" uniqKey="Wu C" first="Chaoyan" last="Wu">Chaoyan Wu</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Integrated Traditional Chinese Medicine and Western medicine, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Integrated Traditional Chinese Medicine and Western medicine, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zeng, Yifei" sort="Zeng, Yifei" uniqKey="Zeng Y" first="Yifei" last="Zeng">Yifei Zeng</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Mengge" sort="Chen, Mengge" uniqKey="Chen M" first="Mengge" last="Chen">Mengge Chen</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Yonghong" sort="Li, Yonghong" uniqKey="Li Y" first="Yonghong" last="Li">Yonghong Li</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xie, Conghua" sort="Xie, Conghua" uniqKey="Xie C" first="Conghua" last="Xie">Conghua Xie</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhou, Yunfeng" sort="Zhou, Yunfeng" uniqKey="Zhou Y" first="Yunfeng" last="Zhou">Yunfeng Zhou</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhong, Yahua" sort="Zhong, Yahua" uniqKey="Zhong Y" first="Yahua" last="Zhong">Yahua Zhong</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yu, Haijun" sort="Yu, Haijun" uniqKey="Yu H" first="Haijun" last="Yu">Haijun Yu</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China; Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Biological Sciences</title><idno type="eISSN">1449-2288</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Loco-regional recurrence of nasopharyngeal carcinoma (NPC) after radiation therapy is one of the main types of treatment failure. This study is aimed to explore the possible causes of inside-field recurrence of NPC patients in order to develop effective treatment methods. Our study indicated that CD44 and autophagy proteins in tumor tissues of patients with recurrent NPC are higher than that of the relapse free patients. The <italic>in vitro</italic> experiments further confirmed that cancer stem cells (CSCs) were more radioresistant with enhanced autophagy activity. Treatment with clioquinol (CQ) combined with zinc could obviously enhance the radiosensitivity of CNE-2s cells through autophagy inhibition, activation of the caspase system and impairment of DNA damage repair. The<italic> in vivo</italic> experiments have further consolidated our findings. Our results suggest that CSCs and enhanced autophagy activity may be involved in the inside-field recurrence of NPC, and CQ combined with zinc could be an important therapeutic approach for recurrent NPC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chua, Mlk" uniqKey="Chua M">MLK Chua</name></author><author><name sortKey="Wee, Jts" uniqKey="Wee J">JTS Wee</name></author><author><name sortKey="Hui, Ep" uniqKey="Hui E">EP Hui</name></author><author><name sortKey="Chan, Atc" uniqKey="Chan A">ATC Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Xiang, J" uniqKey="Xiang J">J Xiang</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Hou, J" uniqKey="Hou 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|area= ChloroquineV1
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|étape= Analysis
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|texte= Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
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